Technology assessment and project evaluation

 

 

PD Dr. med. Michael Nagler, PhD, MSc

 “One question has pre-occuppied me since I started my professional career: How can we improve the medical care of patients? This problem is particularly pressing as health care is changing dramatically. It is recognized that several areas would benefit from significantly more scientific enquiry: diagnostic procedures, predictive measures, monitoring of treatment and effectiveness in clinical practice. To address these questions, the experience of practicing physicians and extensive laboratory expertise as well as profound methodological research knowledge is required. At TAPE, we provide all these skills hand in hand.”

Current healthcare challenges

The needs and requirements imposed on health care systems and health care delivery continue to change dramatically. Health care costs are rising sharply with new diagnostic and therapeutic approaches, and an aging population. The critical appraisal of health care innovations such as diagnostic tools, predictive measures, monitoring tools, as well as treatment schemes, is both essential and difficult. There is however a paucity of studies promoting the implementation of these health care innovations into clinical practice and a major “implementation gap” is acknowledged by health care authorities. The following challenges are apparent:

  • Significantly increasing health care costs 
  • Problems associated with overdiagnosis and overtreatment 
  • New biologicals claim to cure life-threatening diseases
  • Innovative new technologies are rapidly entering the market
  • Demands on medical devices and in-vitro diagnostics are increasing
  • Integration of digital health care in a way that aids healthcare professionals and benefits patient care patient care.

Vision

Delivery of comprehensive laboratory services and expertise, broad experience in clinical medicine as well as profound knowledge in methods of patient-oriented research, to provide all-round expertise including customized solutions to answer patient-oriented research questions. 

Aims and Scope/ What we do

In collaboration with our partners within and beyond the Center for Laboratory Medicine, we address a broad range of major scientific questions.

Unique opportunities at TAPE

The environment TAPE offers a number of unique opportunities:

  1. All-round expertise in laboratory medicine, epidemiology, as well as clinical medicine
  2. Access to a comprehensive spectrum of high-end laboratory technologies (incl. genomics, pharmacogenomics, cytomics, biobanking solutions)
  3. Extensive network of recognized experts in all areas of laboratory medicine and clinical medicine
  4. Large patient numbers at Inselspital including patients with severe and rare diseases
  5. Close collaboration with existing data repositories at Inselspital

Industry Partners

Current projects

Team

Michael Nagler, PhD, MSc
Prof. Dr. Dr. med. Michael Nagler, PhD, MSc
Group leader, Principle Investigator
Anja Stalder
Anja Stalder
Data management
Vincent Benites
Vincent Benites
BMA HF (Laboratory assistant)
Jonas Kaufmann
Jonas Kaufmann
Doctoral thesis (Dr. med.)
Michael Esteves  Pereira
Michael Esteves Pereira
Doctoral thesis (Dr. med.)
Luca Pellegrini
Luca Pellegrini
Doctoral thesis (Dr. med.)
Annika Burger
Annika Burger
Master’s thesis (MD)
Tamara Mertins
Tamara Mertins
Master’s thesis (MD)
Robin Boss
Robin Boss
Master’s thesis (MD)
Daria Eppenberger
Daria Eppenberger
Master’s thesis (MD)
Matthias Knuchel
Matthias Knuchel
Student assistant

Publications

Pubmed

2021

  • Henning Nilius, Tamara Mertins, Robin Boss, Matthias Knuchel, Eva Blozik, Johanna Anna Kremer Hovinga, Sabine Eichinger, Michael Nagler. Long-Term Survival After Venous Thromboembolism: A Prospective Cohort Study. 2021 Oct 1;8:749342. doi: 10.3389/fcvm.2021.749342. PMID: 34660749. PMCID: PMC8517253.
  • Gaby Scheidegger, Zhang Ting Ting, Caroline Bastiaenen, Michael Nagler. Changing Perspectives of Local Therapists Eight Years after the Implementation of an Occupational Therapy Service in a Unique Himalayan Cross-Cultural Setting. 2021 Sep 18;2021:5520195. doi:10.1155/2021/5520195. PMID: 34629994.
  • Tamana Meihandoest, Jan-Dirk Studt, Adriana Mendez, Lorenzo Alberio, Pierre Fontana, Walter A Wuillemin, Adrian Schmidt, Lukas Graf, Bernhard Gerber, Gabriela Monika Maeder, Cédric Bovet, Thomas C Sauter, Michael Nagler. Automated Thrombin Generation Assay for Rivaroxaban, Apixaban, and Edoxaban Measurements. PMID: 34568459. PMCID: PMC8459937. DOI: 10.3389/fcvm.2021.717939.
  • M. Nagler, L. Asmis, B. Gerber, S. Ruosch, D. Spirk, D. Surbek, J.D. Studt, D. A. Tsakiris, W. A. Wuillemin. Venöse Thromboembolie in Gynäkologie und Geburtshilfe. Schweizerisches Medizin-Forum 2021;21(29–30):503–508
  • Sabrina Jegerlehner, Franziska Suter, Philipp Jent, Pascal Bittel, Michael Nagler. Diagnostic accuracy of a SARS-CoV-2 rapid Antigen test in real-life clinical settings: Int J Infect Dis. 2021 Jul 6;S1201-9712(21)00565-8. doi: 10.1016/j.ijid.2021.07.010. Online ahead of print.
  • Guido Willekens, Jan-Dirk Studt, Adriana Mendez, Lorenzo Alberio, Pierre Fontana, Walter A Wuillemin, Adrian Schmidt, Lukas Graf, Bernhard Gerber, Cedric Bovet, Thomas C Sauter, Michael Nagler. A universal anti-Xa assay for rivaroxaban, apixaban, and edoxaban measurements: method validation, diagnostic accuracy and external validation. 2021 May 6. doi: 10.1111/bjh.17470. PMID: 33954979.
  • Justine Brodard, Vincent Benites, Denise Stalder Zeerleder, Michael Nagler. Accuracy of the functional, flow cytometer-based Emo-Test HIT Confirm® for the diagnosis of heparin-induced thrombocytopenia. 2021 Apr 19;203:22-26. doi: 10.1016/j.thromres.2021.04.017. PMID: 33906062.
  • Michael Nagler, Sander M J Van Kuijk, Hugo Ten Cate, Martin H Prins, Arina J Ten Cate-Hoek. Predicting Recurrent Venous Thromboembolism in Patients With Deep-Vein Thrombosis: Development and Internal Validation of a Potential New Prediction Model (Continu-8). 2021 Apr 6;8:655226. doi: 10.3389/fcvm.2021.655226. eCollection 2021. PMID: 33889600.
  • Brigger D, Horn MP, Pennington LF, Powell AE, Siegrist D, Weber B, Engler O, Piezzi V, Damonti L, Iseli P, Hauser C, Froehlich TK, Villiger PM, Bachmann MF, Leib SL, Bittel P, Fiedler M, Largiadèr CR, Marschall J, Stalder H, Kim PS, Jardetzky TS, Eggel A, Nagler M.Accuracy of serological testing for SARS-CoV-2 antibodies: First results of a large mixed-method evaluation study.  Allergy. 2021 Mar;76(3):853-865. doi: 10.1111/all.14608. Epub 2020 Nov 13. PMID: 32997812 Free PMC article.
  • Erdoes G, Birschmann I, Nagler M, Koster A. Andexanet Alfa-Induced Heparin Resistance: When Anticoagulation Really Remains Reversed.  J Cardiothorac Vasc Anesth. 2021 Mar;35(3):908-909. doi: 10.1053/j.jvca.2020.11.052. Epub 2020 Nov 28. PMID: 33339660 No abstract available.
  • Gargiulo G, Nagler M, Valgimigli M. Response by Gargiulo et al to Letter Regarding Article, "Cangrelor, Tirofiban, and Chewed or Standard Prasugrel Regimens in Patients With ST-Segment-Elevation Myocardial Infarction: Primary Results of the FABOLUS FASTER Trial".  Circulation. 2021 Mar 30;143(13):e797-e798. doi: 10.1161/CIRCULATIONAHA.120.051945. Epub 2021 Mar 29. PMID: 33779272 No abstract available.
  • Henning Nilius, Jonas Kaufmann, Adam Cuker, Michael Nagler. Comparative effectiveness and safety of anticoagulants for the treatment of heparin-induced thrombocytopenia. 2021 Apr 15. doi: 10.1002/ajh.26194. PMID: 33857342.
  • Martin Müller, Ioannis Chanias, Michael Nagler, Aristomenis K Exadaktylos, Thomas C Sauter. Falls in ED patients: do elderly patients on direct oral anticoagulants bleed less than those on vitamin K antagonists? 2021 Apr 6;29(1):56. doi: 10.1186/s13049-021-00866-6. PMID: 33823884.
  • Luca Pellegrini, Urban Novak, Martin Andres, Thomas Suter, Michael Nagler. Risk of bleeding complications and atrial fibrillation associated with ibrutinib treatment: A systematic review and meta-analysis. 2021 Jan 27;159:103238. doi: 10.1016/j.critrevonc.2021.103238. Online ahead of print.
  • Michael Esteves Pereira, Christoph Bocksrucker, Johanna Anna Kremer Hovinga, Martin Mueller, Michael Daskalakis, Behrouz Mansouri Taleghani, Michael Nagler. Immunoadsorption for the Treatment of Acquired Hemophilia: New Observational Data, Systematic Review, and Meta-Analysis. 2021 Jan 12;S0887-7963(21)00001-8. PMID: 33518429. DOI: 10.1016/j.tmrv.2021.01.001

2020

  • Jonas Kaufmann, Marcel Adler, Lorenzo Alberio, Michael Nagler. Utility of the Platelet Function Analyzer in Patients with Suspected Platelet Function Disorders: Diagnostic Accuracy Study. 2020 Dec 22;4(4):e427-e436. doi: 10.1055/s-0040-1721502. eCollection 2020 Oct. PMID: 33376942.
  • Gabor Erdoes, Ingvild Birschmann, Michael Nagler, Andreas Koster. Andexanet Alfa-Induced Heparin Resistance: When Anticoagulation Really Remains Reversed. 2020 Nov 28;S1053-0770(20)31287-8.
    doi: 10.1053/j.jvca.2020.11.052. Online ahead of print. PMID: 33339660.
  • Andreas Koster, Gabor Erdoes, Michael Nagler, Ingvild Birschmann, Lorenzo Alberio. How Would Our Own Heparin-Induced Thrombocytopenia Be Treated During Cardiac Surgery? 2020 Nov 5;S1053-0770(20)31178-2. doi: 10.1053/j.jvca.2020.11.002. Online ahead of print. PMID: 33342734.
  • Carola A Huber, Michael Nagler, Thomas Rosemann, Eva Blozik, Markus Näpflin, Stefan Markun
    Trends in Micronutrient Laboratory Testing in Switzerland: A 7-Year Retrospective Analysis of Healthcare Claims Data. Int J Gen Med 2020 Dec 2;13:1341-1348. doi: 10.2147/IJGM.S275406. eCollection 2020.
  • Brigger D, Horn MP, Pennington LF, Powell AE, Siegrist D, Weber B, Engler O, Piezzi V, Damonti L, Iseli P, Hauser C, Froehlich TK, Villiger PM, Bachmann MF, Leib SL, Bittel P, Fiedler M, Largiadèr C, Marschall J, Stalder H, Kim PS, Jardetzky TS, Eggel A, Nagler M. Accuracy of serological testing for SARS-CoV-2 antibodies: first results of a large mixed-method evaluation study. Allergy. 2020 Sep 30. doi: 10.1111/all.14608. Epub ahead of print. PMID: 32997812.
  • Nagler M. Translating Laboratory Tests into Clinical Practice: A Conceptual Framework. Hamostaseologie. 2020 Sep 22. doi: 10.1055/a-1227-8008. Epub ahead of print. PMID: 32961575.
  • Scholz I, Liakoni E, Hammann F, Grafinger KE, Duthaler U, Nagler M, Krähenbühl S, Haschke M. Effects of Hypericum perforatum (St. John's wort) on the pharmacokinetics and pharmacodynamics of rivaroxaban in humans. Br J Clin Pharmacol. 2020 Sep 22. doi: 10.1111/bcp.14553. Epub ahead of print. PMID: 32959922.
  • Kitchen S, de Maat M, Nagler M, Jones R, Lowe A, Burden J, Groneberg K, Rozsnyai G. System performance evaluation of the cobas t 711 and cobas t 511 coagulation analyzers in routine laboratory settings. Blood Coagul Fibrinolysis. 2020 Aug 19. doi: 10.1097/MBC.0000000000000947. Epub ahead of print. PMID: 32826393.
  • Gargiulo G, Esposito G, Avvedimento M, Nagler M, Minuz P, Campo G, Gragnano F, Manavifar N, Piccolo R, Tebaldi M, Cirillo P, Hunziker L, Vranckx P, Leonardi S, Heg D, Windecker S, Valgimigli M. Cangrelor, Tirofiban, and Chewed or Standard Prasugrel Regimens in Patients With ST-Segment-Elevation Myocardial Infarction: Primary Results of the FABOLUS-FASTER Trial. Circulation. 2020 Aug 4;142(5):441-454. doi: 10.1161/CIRCULATIONAHA.120.046928. Epub 2020 Jun 27. PMID: 32795098; PMCID: PMC7392586.
  • Alberio L, Angelillo-Scherrer A, Asmis L, Casini A, Fontana P, Graf L, Hegemann I, Kremer Hovinga JA, Korte W, Lecompte T, Martinez M, Nagler M, Studt JD, Tsakiris DA, Wuillemin W. Recommendations on the use of anticoagulants for the treatment of patients with heparin-induced thrombocytopenia in Switzerland. Swiss Med Wkly. 2020 Apr 24;150:w20210. doi: 10.4414/smw.2020.20210. PMID: 32329806.
  • Casini A, Alberio L, Angelillo-Scherrer A, Fontana P, Gerber B, Graf L, Hegemann I, Korte W, Kremer Hovinga J, Lecompte T, Martinez M, Nagler M, Studt JD, Tsakiris D, Wuillemin W, Asmis L. Thromboprophylaxis and laboratory monitoring for in-hospital patients with COVID-19 - a Swiss consensus statement by the Working Party Hemostasis. Swiss Med Wkly. 2020 Apr 11;150:w20247. doi: 10.4414/smw.2020.20247. PMID: 32277760.
  • Gargiulo G, Esposito G, Cirillo P, Nagler M, Minuz P, Campo G, Gragnano F, Manavifar N, Piccolo R, Avvedimento M, Tebaldi M, Wahl A, Hunziker L, Billinger M, Heg D, Windecker S, Valgimigli M. Facilitation Through Aggrastat or Cangrelor Bolus and Infusion Over PrasugreL: a MUlticenter Randomized Open-label Trial in PatientS with ST-elevation Myocardial InFarction Referred for PrimAry PercutaneouS InTERvention (FABOLUS FASTER) Trial: Design and Rationale : The FABOLUS FASTER Trial. J Cardiovasc Transl Res. 2020 Feb 24. doi: 10.1007/s12265-020-09969-4. Epub ahead of print. PMID: 32096064.
  • Nagler M. CME-Labor 62/Antworten: Wie beurteile ich den Nutzen eines Labortests? Beispiel der D-Dimere [CME Laboratory 62/Answers: How to Assess the Utililty of Laboratory Tests? D-Dimers as an Example]. Praxis (Bern 1994). 2020;109(8):667-668. German. doi: 10.1024/1661-8157/a003493. PMID: 32517605.
  • Nagler M. CME-Labor 62: Wie beurteile ich den Nutzen eines Labortests? Beispiel der D-Dimere [CME Laboratory 62: How to Assess the Utililty of Laboratory Tests? D-Dimers as an Example]. Praxis (Bern 1994). 2020;109(7):539-545. German. doi: 10.1024/1661-8157/a003491. PMID: 32456589.
  • Roost E, Weber A, Alberio L, Englberger L, Reineke D, Keller D, Nagler M, Carrel T. Rivaroxaban in patients with mechanical heart valves: A pilot study. Thromb Res. 2020 Feb;186:1-6. doi: 10.1016/j.thromres.2019.12.005. Epub 2019 Dec 7. PMID: 31837559.
  • Brodard J, Alberio L, Angelillo-Scherrer A, Nagler M. Accuracy of heparin-induced platelet aggregation test for the diagnosis of heparin-induced thrombocytopenia. Thromb Res. 2020 Jan;185:27-30. doi: 10.1016/j.thromres.2019.11.004. Epub 2019 Nov 12. PMID: 31739198.

2019

  • Pollak, M., and M. Nagler (2019) “Thrombophilieabklärung im Hinblick auf östrogenhaltige Kontrazeptiva und Hormonersatztherapie" Gynäkologische Endokrinologie 17:139-147
  • Wolfensberger N, Georgiou G, Giabbani E, Reusser M, Njue LM, Fiedler M, Leichtle AB, Nagler M. Rapid Centrifugation in the Routine Hemostasis Laboratory. Thromb Haemost. 2019 Oct 10. doi: 10.1055/s-0039-1696712. [Epub ahead of print] PubMed PMID: 31600807.
  • Wieland Greguare-Sander, A., W. A. Wuillemin, and M. Nagler (2018) "Utility of thromboelastometry analysis as a diagnostic tool in patients with mild bleedings disorders: a prospective cohort study". European Journal of Anaesthesiology (accepted for publication)
  • Vuilleumier PH, Nagler M, Beldi G, Vogt A. Orthotopic Liver Transplant in a Patient Anticoagulated With Rivaroxaban: A Case Report. A A Pract. 2019 Feb 27.doi: 10.1213/XAA.0000000000000989. [Epub ahead of print]
  • Schnegg-Kaufmann A, Calzavarini S, Limacher A, Mean M, Righini M, Staub D, Beer JH, Frauchiger B, Osterwalder J, Kucher N, Matter CM, Husmann M, Banyai M, Aschwanden M, Mazzolai L, Hugli O, Nagler M, Daskalakis M, Rodondi N, Aujesky D, Angelillo-Scherrer A. A high Gas6 level in plasma predicts venous thromboembolism recurrence, major bleeding and mortality in the elderly: a prospective multicenter cohort study. J Thromb Haemost. 2019 Feb;17(2):306-318.
  • Adler, M., J. Kaufmann, L. Alberio, and M. Nagler (2019) "Diagnostic utility of the ISTH bleeding assessment tool in patients with suspected platelet function disorders”. Journal of Thrombosis and Haemostasis (epub ahead of print)
  • Engelberger, R., V. Schroeder, M. Nagler, R. Prince, D. Periard, D. Hayoz, N. Kucher (2019) “Enhanced thrombolysis by ultrasound-assisted catheter-directed thrombolysis and microbubbles in an in-vitro model of iliofemoral deep vein thrombosis”. Thrombosis and Haemostasis (epub ahead of print)
  • Müller, M., Eastline, J., Nagler, M., Exadaktylos, A.K., Sauter, T. (2019) “Application of prothrombin complex concentrate for reversal of direct oral anticoagulants in clinical practice: indications, patient characteristics and clinical outcomes compared to reversal of vitamin K antagonists” Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine (epub ahead of print)
  • Calzavarini, S., J. Brodard, C. Quarroz, L. Maire, R. Nützi, J. Jankovic, L.C. Rotondo, E. Giabbani, M. Fiedler, M. Nagler, A. Angelillo-Scherrer “Thrombin generation measurement using the ST Genesia Thrombin Generation System in a cohort of healthy adults: normal values and variability”. Research and Practice in Thrombosis and Haemostasis (accepted for publication)
  • Müller M, Bosshard F, Nagler M, Roth B, Exadaktylos AK, Sauter TC. Shorter Hospital Stay and Fewer Hospitalizations in Patients With Visible Hematuria on Direct Oral Anticoagulants Compared to on Vitamin K Antagonists. doi: 10.1016/j.urology.2019.06.004

2018

  • Erdoes G, Schloer H, Eberle B, and Nagler M. Next generation viscoelasticity assays in cardiothoracic surgery: Feasibility of the TEG6s system. PLoS One. 2018 Dec 20;13(12):e0209360
  • Müller M, Schlittler F, Schaller B, Nagler M, Exadaktylos AK, Sauter TC. Characteristics, treatment and outcome of bleeding after tooth extraction in patients on DOAC and phenprocoumon compared to non-anticoagulated patients-a retrospective study of emergency department consultations. Clin Oral Investig. 2018 Oct 5. doi: 10.1007/s00784-018-2676-7. [Epub ahead of print]
  • Bellwald S, Balasubramaniam R, Nagler M, Burri MS, Fischer SDA, Hakim A, Dobrocky T, Yu Y, Scalzo F, Heldner MR, Wiest R, Mono ML, Sarikya H, El-Koussy M, Mordasini P, Fischer U, Schroth G, Gralla J, Mattle HP, Arnold M, Liebeskind D, Jung S. Association of anemia and hemoglobin decrease during acute stroke treatment with infarct growth and clinical outcome. PLoS One. 2018 Se 26;13(9):e0203535
  • Erdoes G, Dietrich W, Stucki MP, Merz TM, Angelillo-Scherrer A, Nagler M, Carrel T, Eberle B. Short-term recovery pattern of plasma fibrinogen after cardiacsurgery: A prospective observational study. PLoS One. 2018 Aug 3;13(8):e0201647
  • Nagler M, Ten Cate H, Prins MH, Ten Cate-Hoek AJ. Risk factors for recurrence in deep vein thrombosis patients following a tailored anticoagulant treatment incorporating residual vein obstruction. Res Pract Thromb Haemost. 2018 Feb 3;2(2):299-309.
  • Bürki S, Brand B, Escher R, Wuillemin WA, and Nagler M. Accuracy, reproducibility and costs of different laboratory assays for the monitoring of unfractionated heparin in clinical practice: a prospective evaluation study and survey among Swiss institutions. BMJ Open. 2018 Jun 9;8(6):e022943
  • Sauter TC, Eberle B, Wuillemin WA, Thiele T, Angelillo-Scherrer A, Exadaktylos AK, Erdoes G, Cuker A, and Nagler M. How I manage patients with anticoagulation-associated bleeding or urgent surgery. Swiss Med Wkly. 2018 Mar 14;148:w14598

2017

  • Nagler M, Angelillo-Scherrer A, Méan M, Limacher A, Abbal C, Righini M, Beer JH, Osterwalder J, Frauchiger B, Aschwanden M, Matter CM, Kucher N, Cornuz J, Banyai M, Husmann M, Staub D, Mazzolai L, Hugli O, Rodondi N, Aujesky D. Long-term outcomes of elderly patients with CYP2C9 and VKORC1 variants treated with vitamin K antagonists. J Thromb Haemost. 2017 Nov;15(11):2165-2175
  • Bankova A, Andres Y, Horn MP, Alberio L, and Nagler M. Rapid immunoassays for diagnosis of heparin-induced thrombocytopenia: Comparison of diagnostic accuracy, reproducibility, and costs in clinical practice. PLoS One. 2017 Jun 8;12(6):e0178289
  • Studt JD, Alberio L, Angelillo-Scherrer A, Asmis LM, Fontana P, Korte W, Mendez A, Schmid P, Stricker H, Tsakiris DA, Wuillemin WA, and Nagler M. Accuracy and consistency of anti-Xa activity measurement for determination of rivaroxaban plasma levels. J Thromb Haemost. 2017 Aug;15(8):1576-1583
  • Bulla O, Poncet A, Alberio L, Asmis LM, Gähler A, Graf L, Nagler M, Studt JD, Tsakiris DA, Fontana P. Impact of a product-specific reference standard for the measurement of a PEGylated rFVIII activity: the Swiss Multicentre Field Study. Haemophilia. 2017 Jul;23(4):e335-e339
  • Sauter TC, Hegazy K, Hautz WE, Krummrey G, Ricklin ME, Nagler M, Borner U, Exadaktylos AK. Epistaxis in anticoagulated patients: Fewer hospital admissions and shorter hospital stays on rivaroxaban compared to phenprocoumon. Clin Otolaryngol. 2018 Feb;43(1):103-108
  • Adler M, Ivic S, Bodmer NS, Ten Cate H, Bachmann LM, Wuillemin WA, and Nagler M. Thromboelastometry and Thrombelastography Analysis under Normal Physiological Conditions - Systematic Review. Transfus Med Hemother. 2017 Apr;44(2):78-83
  • Fontana P, Alberio L, Angelillo-Scherrer A, Asmis LM, Korte W, Mendez A, Schmid P, Stricker H, Studt JD, Tsakiris DA, Wuillemin WA, and Nagler M. Impact of rivaroxaban on point-of-care assays. Thromb Res. 2017 May;153:65-70
  • Nagler M, Cuker A. Profile of Instrumentation Laboratory's HemosIL® AcuStar HIT-Ab(PF4-H) assay for diagnosis of heparin-induced thrombocytopenia. Expert Rev Mol Diagn. 2017 May;17(5):419-426

Publications before 2017

  • Angelillo-Scherrer A, and Nagler M. Thrombophilieabklärung. Ther Umsch. 2016;73(10):626-634
  • Nagler M, Angelillo-Scherrer A. Thromboembolien und Thrombophilie in der Schwangerschaft. Ther Umsch. 2016;73(7):377-383.
  • Nagler M, Bakchoul T. Clinical and laboratory tests for the diagnosis of heparin-induced thrombocytopenia. Thromb Haemost. 2016 Oct 28;116(5):823-834.
  • Sauter TC, Blum S, Nagler M, Schlittler FL, Ricklin ME, Exadaktylos AK. Reversal of Dabigatran Using Idarucizumab in a Septic Patient with Impaired Kidney Function in Real Life Practice. Case Rep Emerg Med. 2016;2016:1393057.
  • Schaefer C, Wuillemin WA, Kessels A, Jacobson A, and Nagler M. Predictors of anticoagulation quality in 15 834 patients performing patient self-management of oral anticoagulation with vitamin K antagonists in real-life practice: a survey of the International Self-Monitoring Association of Orally Anticoagulated Patients. Br J Haematol. 2016 Nov;175(4):677-685.
  • Nagler M, Kremer Hovinga JA, Alberio L, Peter-Salonen K, von Tengg-Kobligk H, Lottaz D, Neerman-Arbez M, Lämmle B. Thromboembolism in patients with congenital afibrinogenaemia. Long-term observational data and systematic review. Thromb Haemost. 2016 Sep 27;116(4):722-32.
  • Nagler M, Bachmann LM, ten Cate H, ten Cate-Hoek A. Diagnostic value of immunoassays for heparin-induced thrombocytopenia: a systematic review and meta-analysis. Blood. 2016 Feb 4;127(5):546-57.
  • Spronk HM, Cannegieter S, Morange P, Hackeng T, Huisman M, Nagler M, Posthuma J, Ninivaggi M, Zwaveling S, van der Hulle T, Scheres LJ, van Mens TE, Mackman N. Theme 2: Epidemiology, Biomarkers, and Imaging of Venous Thromboembolism (and postthrombotic syndrome). Thromb Res. 2015 Sep;136 Suppl 1:S8-S12.
  • Adler M, and Nagler M. Adherence to treatment with non-vitamin K antagonist anticoagulants: once- vs. twice-daily regimens. Europace. 2015 Aug;17(8):1316.
  • Nagler M, Wuillemin WA. Patient self-management of oral anticoagulation with vitamin K antagonists in everyday practice. Br J Haematol. 2015 May;169(4):600-1.
  • Nagler M, Ten Cate H. Thromboelastometry changes in myeloproliferative neoplasms-surrogate for a procoagulant haemostatic imbalance or a consequence of technical reasons? Ann Hematol (2013) 92:1633-1639
  • Nagler M, Angelillo-Scherrer A. Diagnostic value of the 4Ts score for heparin-induced thrombocytopenia in the critically ill. J Crit Care. 2014 Dec;29(6):1126-7
  • Nagler M, Keller P, Siegrist D, Alberio L. A case of EDTA-dependent pseudothrombocytopenia: simple recognition of an underdiagnosed and misleading phenomenon. BMC Clin Pathol. 2014 May 1;14:19
  • Nagler M, Bachmann LM, Schmid P, Raddatz Müller P, Wuillemin WA. Patient self-management of oral anticoagulation with vitamin K antagonists in everyday practice: efficacy and safety in a nationwide long-term prospective cohort study. PLoS One. 2014 Apr 18;9(4):e95761
  • Nagler M, ten Cate H, Kathriner S, Casutt M, Bachmann LM, Wuillemin WA. Consistency of thromboelastometry analysis under scrutiny: results of a systematic evaluation within and between analysers. Thromb Haemost. 2014 Jun;111(6):1161-6.
  • Simeon L, Nagler M, Wuillemin WA. [New oral anticoagulants - influence on coagulation tests]. Dtsch Med Wochenschr. 2014 Jan;139(3):94-9
  • Nagler M, Bachmann LM, Alberio L, Angelillo-Scherrer A, Asmis LM, Korte W, Mendez A, Reber G, Stricker H, Tsakiris DA, Wuillemin WA. Variability between laboratories performing coagulation tests with identical platforms: a nationwide evaluation study. Thromb J. 2013 Mar 7;11(1):6.
  • Nagler M, Kathriner S, Bachmann LM, Wuillemin WA. Impact of changes in haematocrit level and platelet count on thromboelastometry parameters. Thromb Res. 2013 Mar;131(3):249-53
  • Nagler M, Raddatz-Müller P, Schmid P, Bachmann LM, Wuillemin WA. Accuracy of the point-of-care coagulometer CoaguChek XS in the hands of patients. J Thromb Haemost. 2013 Jan;11(1):197-9.
  • Nagler M, Wuillemin W. [Laboratory diagnostic with regard to new anticoagulants - monitoring and influence on coagulation tests]. Ther Umsch. 2012 Nov;69(11):650-6.
  • Nagler M, Feller S, Beyeler C. Retrospective adjustment of self-assessed medical competencies - noteworthy in the evaluation of postgraduate practical training courses. GMS Z Med Ausbild. 2012;29(3):Doc45.
  • Nagler M, Haslauer M, Wuillemin WA. Fondaparinux - data on efficacy and safety in special situations. Thromb Res. 2012 Apr;129(4):407-17
  • Nagler M, Fabbro T, Wuillemin WA. Prospective evaluation of the interobserver reliability of the 4Ts score in patients with suspected heparin-induced thrombocytopenia. J Thromb Haemost. 2012 Jan;10(1):151-2.
  • Nagler M, Gregor M, Wuillemin WA. Iron chelation with deferasirox in two patients with HFE hemochromatosis and chronic anemia. Acta Haematol. 2011;126(2):119-21.
  • Nagler M, Wuillemin WA. Leeching as a substitute for phlebotomy. Br J Haematol. 2011 May;153(4):420
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  • Nagler M, Haslauer M, Wuillemin WA. Long-term anticoagulation with fondaparinux in a patient with a mechanical heart valve. Ann Hematol. 2011 Oct;90(10):1225-6.
  • Nagler M, Müller B, Briner V, Winterhalder R. Severe hyperkalemia and bilateral adrenal metastasis. J Oncol. 2009;2009:831979